The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer

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dc.authoridhttps://orcid.org/0000-0002-7538-7399
dc.authoridhttps://orcid.org/0000-0003-4638-1059
dc.authoridhttps://orcid.org/0000-0002-1230-7777
dc.contributor.authorİlhan, Burak
dc.contributor.authorEnder, Şenol
dc.contributor.authorKılıç, Berkay
dc.contributor.authorÜçüncü, Muhammed
dc.contributor.authorSerilmez, Murat
dc.contributor.authorYasasever, Ceren Tilgen
dc.contributor.authorSoydinç, Hilal Oğuz
dc.contributor.authorKuras, Sibel
dc.contributor.authorErdoğan, Bekir
dc.contributor.authorAlsaadoni, Hani
dc.contributor.authorKaranlık, Hasan
dc.contributor.authorBademler, Süleyman
dc.date.accessioned2025-03-25T12:54:08Z
dc.date.available2025-03-25T12:54:08Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Meslek Yüksekokulu
dc.description.abstractDespite advances in cancer treatment, breast cancer (BC) remains one of the most common cancers affecting women worldwide. This study aimed to determine serum circFBXW7, circABCB10, and circ0103552 levels and compare BC patients and healthy controls to investigate their roles in the molecular mechanism of BC and the significance of these circRNAs in BC diagnosis. The study group consisted of 92 patients with BC and 31 healthy controls. Total RNA was isolated from serum samples. Following total RNA, complementary DNA was synthesized from this material. Following complementary DNA analysis, the circRNA levels were analyzed by the qRT-PCR method. Expression levels were evaluated in ∆Ct values. High ∆Ct values of circFBXW7 and circ0103552 and low ∆Ct values of circABCB10 were correlated with BC diagnosis (circFBXW7, p = 0.043, r = 0.183, circ0103552, p < 0.001, r = 0.321, circABCB10, p = 0.001, r = −0.291). According to Fold Change (FC) values, circFBXW7 (FC = 0.30) and circ0103552 (FC = 0.26) showed low expression in the patient group compared to the control group, while circABCB10 (FC = 11.09) showed high expression (p < 0.05, for all comparisons). We think that our study is one of the rare studies investigating the relationship between BC and serum circRNA levels. This study concludes that the significant downregulation of circFBXW7 and circ0103552 and the upregulation of circABCB10 are directly related to the diagnosis of BC and can be used for diagnosis, but further studies are needed to elucidate the molecular mechanism of the relationship between circRNAs and BC.
dc.identifier.citationIlhan, B.; Ender, ¸S.; Kılıç, B.; Üçüncü, M.; Serilmez, M.; Tilgen Yasasever, C.; O˘guz Soydinç, H.; Kuras, S.; Erdo˘gan, B.; Alsaadoni, H.; et al. The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer. Curr. Issues Mol. Biol. 2024, 46, 14381–14393. https://doi.org/ 10.3390/cimb46120862
dc.identifier.doi10.3390/cimb46120862
dc.identifier.endpage14393
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue12
dc.identifier.startpage14381
dc.identifier.urihttps://hdl.handle.net/11363/9601
dc.identifier.volume46
dc.identifier.wos001385452500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÜçüncü, Muhammed
dc.institutionauthoridhttps://orcid.org/0000-0003-4638-1059
dc.language.isoen
dc.publisherMDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
dc.relation.ispartofCURRENT ISSUES IN MOLECULAR BIOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcircFBXW7
dc.subjectcircABCB10
dc.subjectcirc0103552
dc.subjectcircRNA
dc.subjectbreast cancer
dc.titleThe Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer
dc.typeArticle

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