The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer
Yükleniyor...
Dosyalar
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Despite advances in cancer treatment, breast cancer (BC) remains one of the most common
cancers affecting women worldwide. This study aimed to determine serum circFBXW7, circABCB10,
and circ0103552 levels and compare BC patients and healthy controls to investigate their roles in
the molecular mechanism of BC and the significance of these circRNAs in BC diagnosis. The study
group consisted of 92 patients with BC and 31 healthy controls. Total RNA was isolated from
serum samples. Following total RNA, complementary DNA was synthesized from this material.
Following complementary DNA analysis, the circRNA levels were analyzed by the qRT-PCR method.
Expression levels were evaluated in ∆Ct values. High ∆Ct values of circFBXW7 and circ0103552 and
low ∆Ct values of circABCB10 were correlated with BC diagnosis (circFBXW7, p = 0.043, r = 0.183,
circ0103552, p < 0.001, r = 0.321, circABCB10, p = 0.001, r = −0.291). According to Fold Change (FC)
values, circFBXW7 (FC = 0.30) and circ0103552 (FC = 0.26) showed low expression in the patient group
compared to the control group, while circABCB10 (FC = 11.09) showed high expression (p < 0.05, for
all comparisons). We think that our study is one of the rare studies investigating the relationship
between BC and serum circRNA levels. This study concludes that the significant downregulation of
circFBXW7 and circ0103552 and the upregulation of circABCB10 are directly related to the diagnosis
of BC and can be used for diagnosis, but further studies are needed to elucidate the molecular
mechanism of the relationship between circRNAs and BC.
Açıklama
Anahtar Kelimeler
circFBXW7, circABCB10, circ0103552, circRNA, breast cancer
Kaynak
CURRENT ISSUES IN MOLECULAR BIOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
46
Sayı
12
Künye
Ilhan, B.; Ender, ¸S.; Kılıç, B.;
Üçüncü, M.; Serilmez, M.; Tilgen
Yasasever, C.; O˘guz Soydinç, H.;
Kuras, S.; Erdo˘gan, B.; Alsaadoni, H.;
et al. The Diagnostic Value of
circFBXW7, circABCB10, and
circ0103552 Levels in Breast Cancer.
Curr. Issues Mol. Biol. 2024, 46,
14381–14393. https://doi.org/
10.3390/cimb46120862
