Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and alpha-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players

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dc.contributor.authorUlucan, Korkut
dc.contributor.authorSercan, Canan
dc.contributor.authorBıyıklı, Türker
dc.date.accessioned2019-01-19T19:03:45Z
dc.date.available2019-01-19T19:03:45Z
dc.date.issued2015-08-26
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractAngiotensin-1 converting enzyme (ACE) gene and a-actinin-3 (ACTN3) gene polymorphisms are considered to be the most important candidate genes for genetic predisposition to human athletic performance. In the present study, we aimed to analyze the distribution of ACE and ACTN3 polymorphisms for the first time in male Turkish soccer players. In this prospective study, our cohort consisted of 25 professional players, all with Turkish ancestry. Polymerase chain reaction (PCR)-restriction length polymorphism was used for the characterization of the genotype of ACTN3 and single PCR for ACE. For ACE genotype, 16%, 44%, and 40% of the players had insertion/insertion (II), insertion/deletion (ID), and deletion/deletion (DD) genotypes, respectively, whereas 20% had XX, 36% had RX, and 44% had RR genotypes for ACTN3. When we examined the allelic percentages, for ACE, D allele was recorded as 62 and I as 38, and for ACTN3, R allele was 62 and X was 38. Our results were in agreement with the previous reports, indicating the presence of ACTN3 D and ACE X allele in soccer players. We suggest that ACE and ACTN3 genotypes are important biomarkers for genetic counseling for the individuals who are prone to be successful soccer players.en_US
dc.identifier.doi10.4137/GEG.S31479en_US
dc.identifier.endpage4en_US
dc.identifier.issn1179-237X
dc.identifier.pmid26448692en_US
dc.identifier.scopus2-s2.0-84945964991en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/907
dc.identifier.urihttps://doi.org/
dc.identifier.volume7en_US
dc.identifier.wosWOS:000215910400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDen_US
dc.relation.ispartofGenetics & Epigeneticsen_US
dc.relation.publicationcategoryKategori Yoken_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Geneticsen_US
dc.subjectResearch Subject Categories::SOCIAL SCIENCES::Social sciences::Social work::Sports researchen_US
dc.titleDistribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and alpha-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Playersen_US
dc.typeArticleen_US

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