Functional connectivity patterns in parosmia

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dc.authoridhttps://orcid.org/0000-0002-5349-9699en_US
dc.contributor.authorThaploo, Divesh
dc.contributor.authorJoshi, Akshita
dc.contributor.authorYılmaz, Eren
dc.contributor.authorYıldırım, Düzgün
dc.contributor.authorAltundağ, Aytuğ
dc.contributor.authorHummel, Thomas
dc.date.accessioned2024-05-29T23:03:12Z
dc.date.available2024-05-29T23:03:12Z
dc.date.issued2023en_US
dc.departmentSağlık Bilimleri Fakültesien_US
dc.description.abstractObjective Parosmia is a qualitative olfactory dysfunction presenting as“distorted odor perception” in presence of an odor source. Aim of this study was to use resting state functional connectivity to gain more information on the alteration of olfactory processing at the level of the central nervous system level. Methods A cross sectional study was performed in 145 patients with parosmia (age range 20–76 years; 90 women). Presence and degree of parosmia was diagnosed on the basis of standardized questionnaires. Participants also received olfactory testing using the “Snifn’ Sticks”. Then they underwent resting state scans using a 3 T magnetic resonance imaging scanner while fxating on a cross. Results Whole brain analyses revealed reduced functional connectivity in salience as well as executive control networks. Region of interest-based analyses also supported reduced functional connectivity measures between primary and secondary olfactory eloquent areas (temporal pole, supramarginal gyrus and right orbitofrontal cortex; dorsolateral pre-frontal cortex and the right piriform cortex). Conclusions Participants with parosmia exhibited a reduced information fow between memory, decision making centers, and primary and secondary olfactory areas.en_US
dc.identifier.doi10.1186/s12993-023-00225-8en_US
dc.identifier.endpage9en_US
dc.identifier.issn1744-9081
dc.identifier.issue1en_US
dc.identifier.pmid38115149en_US
dc.identifier.scopus2-s2.0-85180243090en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/7410
dc.identifier.urihttps://doi.org/
dc.identifier.volume19en_US
dc.identifier.wosWOS:001129430700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Eren
dc.language.isoenen_US
dc.publisherBMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLANDen_US
dc.relation.ispartofBEHAVIORAL AND BRAIN FUNCTIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParosmiaen_US
dc.subjectFunctional connectivityen_US
dc.subjectHyposmiaen_US
dc.subjectSalienceen_US
dc.subjectExecutive controlen_US
dc.titleFunctional connectivity patterns in parosmiaen_US
dc.typeArticleen_US

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