Expression of CYP and GST in human normal and colon tumor tissues

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dc.authoridhttp://orcid.org/0000-0002-5892-3735en_US
dc.authoridhttp://orcid.org/0000-0002-7581-1604en_US
dc.authoridhttp://orcid.org/0000-0001-9987-0572en_US
dc.authoridhttp://orcid.org/0000-0002-3689-3061en_US
dc.authoridhttp://orcid.org/0000-0002-7280-4417en_US
dc.authoridhttp://orcid.org/0000-0001-9210-5851en_US
dc.contributor.authorBuluş, Hakan
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorGüler Şimşek, Gülçin
dc.contributor.authorKılıç, Murat
dc.contributor.authorAda, Ahmet Oğuz
dc.contributor.authorGöl, Saliha
dc.contributor.authorKaya Koçdoğan, Arzu
dc.contributor.authorKaygın, Pınar
dc.contributor.authorBozer, Büşra
dc.contributor.authorİşcan, Mümtaz
dc.date.accessioned2023-11-30T07:29:42Z
dc.date.available2023-11-30T07:29:42Z
dc.date.issued2019en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractWe investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development.en_US
dc.identifier.doi10.1080/10520295.2018.1493220en_US
dc.identifier.endpage9en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid30092668en_US
dc.identifier.scopus2-s2.0-85051954497en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/6584
dc.identifier.urihttps://doi.org/
dc.identifier.volume94en_US
dc.identifier.wosWOS:000458977400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaya Koçdoğan, Arzu
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLANDen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenocarcinomaen_US
dc.subjectcolonen_US
dc.subjectcytochrome P450en_US
dc.subjectglutathione-S-transferaseen_US
dc.subjecthumanen_US
dc.subjectsmoking statusen_US
dc.titleExpression of CYP and GST in human normal and colon tumor tissuesen_US
dc.typeArticleen_US

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