The Administration of Steroids and its Impact on Caspase-3 Expression in Pediatric Adenoid Hypertrophy

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dc.authoridDirican, Onur/0000-0003-0511-6611
dc.contributor.authorApaydin, Emre
dc.contributor.authorYasar, Buse
dc.contributor.authorSimsek, Gulcin
dc.contributor.authorKaygin, Pinar
dc.contributor.authorSarialtin, Sezen Yilmaz
dc.contributor.authorDirican, Onur
dc.contributor.authorCetin, Hazal Eylem
dc.date.accessioned2024-09-11T19:50:30Z
dc.date.available2024-09-11T19:50:30Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjectiveAdenoid hypertrophy is a prevalent pediatric condition, often necessitating surgical intervention. Intranasal steroid administration shows promise as a conservative treatment, particularly by inducing apoptosis in adenoidal cells, leading to a reduction in adenoid size and inflammation. This study aims to characterize the expression profile of caspase-3 as an apoptotic inducer protein in inflammatory and epithelial adenoid tissues and explore its association with steroid administration. MethodsWe performed immunohistochemical staining for caspase-3 proteins in adenoid tissues obtained from 51 pediatric patients aged between 2.5 and 12 years (mean age: 6.09 +/- 2.1 years) who underwent adenoid surgery. A retrospective analysis of clinical data was conducted, categorizing participants into steroid treatment receivers (n = 25) and non-receivers (n = 26). Subsequently, the lymphoid inflammatory tissue and epithelial tissue from the adenoid were compared in terms of caspase-3 protein expression, and associated clinical variables were assessed. ResultsImmunohistochemical analysis revealed significant caspase-3 expression in inflammatory tissues. The expression levels were scored, and no significant correlation was observed between inflammation and epithelium based on caspase-3 expression (correlation coefficient = 0.143; p > 0.05). Furthermore, demographic and clinical characteristics did not show a statistically significant difference in caspase-3 expression levels. ConclusionCaspase-3 expression was significant in inflammatory adenoid tissue, but it showed no association with nasal steroid administration.en_US
dc.description.sponsorshipUniversity of Kimath;rimath;kkale, scientific [2022/052]en_US
dc.description.sponsorshipThis study has been supported by University of K & imath;r & imath;kkale, scientific research projects coordination unit grant No 2022/052. DAS:The authors confirm that all data supporting the finding of the study are available within the article, and the raw data supporting the findings were generated and available at the corresponding author on request.en_US
dc.identifier.doi10.1007/s12070-024-04900-8
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.scopus2-s2.0-85198947894en_US
dc.identifier.urihttps://doi.org/10.1007/s12070-024-04900-8
dc.identifier.urihttps://hdl.handle.net/11363/7638
dc.identifier.wosWOS:001272643400005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Otolaryngology And Head & Neck Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAdenoid Hypertrophyen_US
dc.subjectPediatricen_US
dc.subjectCaspase-3en_US
dc.subjectImmunohistochemicalen_US
dc.subjectInflammationen_US
dc.subjectEpitheliumen_US
dc.titleThe Administration of Steroids and its Impact on Caspase-3 Expression in Pediatric Adenoid Hypertrophyen_US
dc.typeArticleen_US

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