Describing the Expression Profiles of Glutathione S-Transferase Mu and Tumor Protein 53 in Brain Tumor Tissue

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dc.authoridYILMAZ, Can/0000-0002-0028-6614
dc.authoridDirican, Onur/0000-0003-0511-6611
dc.contributor.authorDirican, Onur
dc.contributor.authorKaygin, Pinar
dc.contributor.authorLti, Sezen Yilmaz Saria
dc.contributor.authorYilmaz, Can
dc.contributor.authorSimsek, Gulcin
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorCoban, Tuelay
dc.date.accessioned2024-09-11T19:52:34Z
dc.date.available2024-09-11T19:52:34Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjective: This study aims to explore the expression profiles of the glutathione S-transferaseMu (GST-M) isozyme and tumor protein 53 (p53) in both healthy and tumorous brain tissues. The findings are compared with clinical features and lifestyle factors to identify potential associations or correlations. Materials and Methods: We retrospectively analyzed the medical records of 149 patients diagnosed with primary or metastatic intracranial tumors. The expression levels of GST-M and p53 proteins were assessed in healthy and tumorous brain tissues using immunohistochemical staining. We also evaluated the associated clinical features and lifestyle factors. Results: There was a significant difference in the expression levels of GST-M between tumorous and healthy brain tissues, with tumor tissues showing higher expression (p<0.0001). Conversely, robust p53 expression was absent in both normal (97.3%) and tumor (78.5%) tissues. Nevertheless, a significantly higher prevalence of samples with p53 expression was found in the tumor group (p<0.0001). No associations were found between expression levels and clinical features or lifestyle risk factors. Furthermore, GST-M and p53 expression did not impact postoperative survival rates. Conclusion: The findings indicate an elevated expression of GST-M in brain tumor tissues, suggesting a potential role for GST-M in brain tumorigenesis.en_US
dc.identifier.doi10.14744/cpr.2024.77834
dc.identifier.endpage223en_US
dc.identifier.issn2980-2156
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.14744/cpr.2024.77834
dc.identifier.urihttps://hdl.handle.net/11363/7979
dc.identifier.volume46en_US
dc.identifier.wosWOS:001244721800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofJournal of Clinical Practice And Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectBrain canceren_US
dc.subjectimmunohistochemistryen_US
dc.subjectglutathione S-transferaseen_US
dc.subjecttumor protein 53en_US
dc.subjectlifestyleen_US
dc.titleDescribing the Expression Profiles of Glutathione S-Transferase Mu and Tumor Protein 53 in Brain Tumor Tissueen_US
dc.typeArticleen_US

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