Comparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary study

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dc.authoridhttps://orcid.org/0000-0001-8057-3463en_US
dc.authoridhttps://orcid.org/0000-0002-4564-0322en_US
dc.authoridhttps://orcid.org/0000-0003-4333-8274en_US
dc.authoridhttps://orcid.org/0000-0001-5933-2913en_US
dc.contributor.authorUzunçakmak, Tuğba Kevser
dc.contributor.authorKoska, Mahmut Can
dc.contributor.authorÖzkanlı, Şeyma
dc.contributor.authorKaya Koçdoğan, Arzu
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorKaradağ, Ayşe Serap
dc.contributor.authorAkdeniz, Necmettin
dc.contributor.authorWollina, Uwe
dc.date.accessioned2023-09-23T17:45:14Z
dc.date.available2023-09-23T17:45:14Z
dc.date.issued2020en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractMorphea is an inflammatory connective tissue disorder, which is characterized by sclerosis in skin and subcutaneous tissues with a chronic progress. The oxidative stress in pathogenesis of sclerosing diseases was proposed in several studies with conflicting results. To explore the tissue expressions of Glutathione S transferase (GST) isoenzymes in patients with morphea and compare these expressions with healthy controls. Twenty-two morphea patients and 20 sex and age matched healthy controls were enrolled in this study. Four millimeter punch biopsies were performed from the active sclerotic plaques of morphea patients. Tissue samples of control group were obtained from nonlesional normal skin biopsy specimens. The protein expressions of GST isoenzymes were analyzed immunohistochemically. Tissue expressions of GSTP1, GSTT1, and GSTA1 isoenzymes in morphea patients were found to be significantly higher than in control tissues. There was no significant difference in GSTM1 isoenzyme expression between the two groups. The increased tissue expressions of GSTA1, GSTP1, and GSTT1 isoenzymes in morphea may represent the activated GST enzymes in response to excessive free radical formation and may also support the hypothesis of increased oxidative stress in morphea etiopathogenesis.en_US
dc.identifier.doi10.1111/dth.14363en_US
dc.identifier.endpage6en_US
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid33002252en_US
dc.identifier.scopus2-s2.0-85092151961en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11363/5636
dc.identifier.urihttps://doi.org/
dc.identifier.volume33en_US
dc.identifier.wosWOS:000575935200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaya Koçdoğan, Arzu
dc.language.isoenen_US
dc.publisherWILEY-HINDAWI, ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON WIT 5HE, ENGLANDen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectdermatopathologyen_US
dc.subjectglutathione S transferaseen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlocalized sclerodermaen_US
dc.subjectmorpheaen_US
dc.subjectoxidative stressen_US
dc.titleComparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary studyen_US
dc.typeArticleen_US

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