Long-Term Outcomes of Allogeneic Stem Cell Transplantation for Relapsed/Refractory Hodgkin and Non-Hodgkin Lymphoma: Multi-center Experience from Turkey

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dc.contributor.authorUysal, Ayse
dc.contributor.authorSoyer, Nur Akad
dc.contributor.authorOzdogu, Hakan
dc.contributor.authorGoker, Hakan
dc.contributor.authorCinar, Olgu Erkin
dc.contributor.authorDeveci, Burak
dc.contributor.authorYilmaz, Asu Fergun
dc.date.accessioned2024-09-11T19:50:32Z
dc.date.available2024-09-11T19:50:32Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractThis multicenter retrospective study evaluated the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on survival and safety in patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A total of 110 patients with R/R HL or NHL who underwent allo-HSCT between July 2007 and October 2022 at 7 adult stem cell transplant centers were evaluated. Progression-free survival (PFS), graft versus host disease-free survival (GRFS), and overall survival (OS) were the primary endpoints, and NRM was the secondary endpoint. Forty-one (37.3%) of the total patients were diagnosed with HL, 69 (62.7%) with NHL. The median age at the time of allo-HCT was 39.5 years (16-67), of which 66 (60%) were male. The median follow-up was 67.5 +/- 8.1 months, and the rates of 5-year OS, PFS, and GRFS were 38.4%, 37%, and 34.8%, respectively. On multivariate analysis, CR/PR disease status after allo-HCT was significantly associated with longer PFS (HR: 13.47, 95% CI: 5.80-31.26, p = 0.000) and OS (HR: 5.23, 95% CI: 2.93-9.34, p = 0.000). CR/PR disease status after allo-HCT (HR: 5.79, 95% CI: 3.22-10.40, p = 0.000) and grade 1-2 acute GvHD (HR: 2.33, 95% CI: 1.25-4.35, p = 0.008) were significantly associated with longer GRFS. The 5-year cumulative incidence of NRM was 24.8% (95% CI, 12.5-36.7). The most common conditioning regimen was reduced intensity. Transplant outcomes are not influenced by disease subtype. However, the achievement of a CR/PR response after allo-HCT significantly prolongs OS, PFS and GRFS. In addition, the presence of acute grade 1-2 GvHD was found to be another factor prolonging GRFS. These results support the feasibility of allo-HCT, especially in heavily treated patients.en_US
dc.description.sponsorshipThe authors thank Isabel Raika Durusoy for assistance with statistical analysis.en_US
dc.identifier.doi10.1007/s12288-024-01800-3
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.scopus2-s2.0-85199602579en_US
dc.identifier.urihttps://doi.org/10.1007/s12288-024-01800-3
dc.identifier.urihttps://hdl.handle.net/11363/7643
dc.identifier.wosWOS:001276944200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Hematology And Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAllogeneic hematopoietic stem cell transplantationen_US
dc.subjectGraft versus host disease-free relapse-free survivalen_US
dc.subjectLymphomaen_US
dc.subjectProgression-free survivalen_US
dc.subjectOverall survivalen_US
dc.titleLong-Term Outcomes of Allogeneic Stem Cell Transplantation for Relapsed/Refractory Hodgkin and Non-Hodgkin Lymphoma: Multi-center Experience from Turkeyen_US
dc.typeArticleen_US

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