Effect of breast cancer and breast cancer treatment on the blood serum concentrations of trace elements and selenoproteins

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dc.authoridhttps://orcid.org/0000-0003-2420-8415en_US
dc.authoridhttps://orcid.org/0000-0003-1406-864Xen_US
dc.authoridhttps://orcid.org/0000-0001-9559-4515en_US
dc.contributor.authorÖğüt, Selim
dc.contributor.authorBahtiyar, Nurten
dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorCinemre, Fatma Behice
dc.contributor.authorAydemir, Birsen
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorDeğirmencioğlu, Sevgin
dc.contributor.authorHacıosmanoğlu, Ebru
dc.contributor.authorKural, Alev
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorGüneş, Mehmet Emin
dc.contributor.authorBektaş, Muhammet
dc.date.accessioned2023-10-02T07:03:54Z
dc.date.available2023-10-02T07:03:54Z
dc.date.issued2022en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractTrace elements (TEs) playing critical roles in chemical events that occur at the cellular level in the body are necessary for biological processes in human health. The role of TEs and selenoproteins and their relationship with breast cancer (BC) have not been studied thoroughly and therefore remain relatively unknown. Our study aimed to investigate possible changes in the serum selenoproteins (Glutathione Peroxidase 1 (GPX1), Glutathione Peroxidase 6 (GPX6), Selenoprotein F (Sel-F), Selenoprotein H (Sel-H), Selenoprotein S (Sel-S), Selenoprotein V (Sel-V), Selenoprotein M (Sel-M)), and TEs (Se, Zn, Mn, Cu, and Fe) levels, and TEs ratios (Fe/Se, Fe/Zn, Fe/Mn, Cu/Se, Cu/Zn, and Cu/Mn) in patients with BC before and after treatment (surgery, radiotherapy, and chemotherapy), and to evaluate the results in the patient groups with healthy controls. A total of 35 patients with BC and 25 healthy subjects were included in the study. Blood samples were collected from the patient group on the day prior to treatment, and on the day treatment was completed. Serum GPX1, GPX6, Sel- F, Sel-H, and Sel-S levels were decreased in both before and after treatment groups compared to the control. The treatment of BC resulted in increasing the concentration of Sel-V compared to before treatment levels. The treatment of BC resulted in lowering serum Se, Zn, and Fe concentrations compared to before treatment levels. Also, serum Se, Zn, and Fe levels were decreased in both before and after treatment groups compared to the control. The ratios of Cu/Se, Cu/Zn, and Cu/Mn were increased after treatment compared to the values before treatment. Cu/Se and Cu/Zn ratios were increased, but Fe/Mn ratios were decreased after treatment compared to healthy control. This study indicates that changes in serum levels of TEs such as Zn, Mn, Cu, and Se, as well as their ratios and selenoproteins, may be related to the treatments of BC. Further studies are required to clarify the exact specific mechanisms involved in the status of TEs and selenoproteins in therapeutic strategies of BC.en_US
dc.identifier.doi10.5601/jelem.2022.27.1.2216en_US
dc.identifier.endpage302en_US
dc.identifier.issn1644-2296
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85131885447en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://hdl.handle.net/11363/5719
dc.identifier.urihttps://doi.org/
dc.identifier.volume27en_US
dc.identifier.wosWOS:000806407800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÖğüt, Selim
dc.language.isoenen_US
dc.publisherPOLISH SOCIETY MAGNESIUM RESEARCH, UNIV WARMIA-MAZURY OLSZTYN, PLAC LODZKI 2, OLSZYTN PLS 10-957, POLANDen_US
dc.relation.ispartofJournal of Elementologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectbreast canceren_US
dc.subjecttreatmenten_US
dc.subjectselenoproteinsen_US
dc.subjectseleniumen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.subjectironen_US
dc.subjectmanganeseen_US
dc.titleEffect of breast cancer and breast cancer treatment on the blood serum concentrations of trace elements and selenoproteinsen_US
dc.typeArticleen_US

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