Synergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro study

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dc.authoridhttp://orcid.org/0000-0002-6086-5490en_US
dc.authoridhttps://orcid.org/0000-0002-5411-5925en_US
dc.authoridhttps://orcid.org/0000-0001-9670-2426en_US
dc.authoridhttps://orcid.org/0000-0003-0889-0223en_US
dc.contributor.authorÖzdal Zincir, Özge
dc.contributor.authorÖzdal, Umut
dc.contributor.authorÜnlü, Özge
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorKatiboğlu, Ahmet Bülent
dc.contributor.authorEgil, Edibe
dc.contributor.authorAltan Şallı, Gülay
dc.date.accessioned2023-08-11T14:45:05Z
dc.date.available2023-08-11T14:45:05Z
dc.date.issued2021en_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.description.abstractThe efectiveness of antifungal agents may be insufcient against resistant strains in some cases of oral candidiasis. The aim of this study was to evaluate the antifungal efect of thymoquinone against Candida albicans, Candida tropicalis, Candida glabrata and Candida krusei strains and the synergistic antifungal activity of these strains in combination with nystatin. To evaluate in vitro antifungal activity and interactions between thymoquinone and nystatin, substances were tested against Candida albicans ATCC 10,231, C. tropicalis ATCC 750, C.krusei ATCC 6258 and C. glabrata ATCC 2001 standard strains both individually and combinationally via microdilution method. MIC and ?FIC index value were analysed. The Kruskal Wallis test and Bonferroni test were used for statistical evaluations. Statistical signifcance was set at p<0.05. A statistically signifcant diference was observed between the mean ranks of all Candida species and doses of thymoquinone, nystatin, and the combination thymoquinone-nystatin (p<0.05). MIC values for thymoquinone were determined as 15 ?g/mL for C. albicans, C. tropicalis and C. krusei while it was 30 ?g/mL for C. glabrata. Moreover, MIC for nystatin was found as 1.875 ?g/mL for C. albicans, C. tropicalis and C. krusei, whereas it was 7.5 ?g/mL in C. glabrata. Interaction assays and ?FIC index value revealed that, TQ and nystatin have a synergistic efect against to all strains. Thymoquinone was found to have antifungal activity on Candida species and synergistic efect when combined with nystatin.en_US
dc.identifier.doi10.1007/s10266-021-00667-4en_US
dc.identifier.endpage337en_US
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.issue2en_US
dc.identifier.pmid34657217en_US
dc.identifier.scopus2-s2.0-85117572071en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage330en_US
dc.identifier.urihttps://hdl.handle.net/11363/5251
dc.identifier.urihttps://doi.org/
dc.identifier.volume110en_US
dc.identifier.wosWOS:000707922100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdal Zincir, Özge
dc.institutionauthorEgil, Edibe
dc.language.isoenen_US
dc.publisherSPRINGER, ONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATESen_US
dc.relation.ispartofOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectThymoquinoneen_US
dc.subjectCandidaen_US
dc.subjectAntifungal drugsen_US
dc.subjectSynergistic efecten_US
dc.subjectOral candidiasisen_US
dc.titleSynergistic effect of thymoquinone and nystatin in the treatment of oral candidiasis; an in vitro studyen_US
dc.typeArticleen_US

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