Molecular epidemiology of Hepatitis B virus, Hepatitis C virus, and Hepatitis D virus in general population of Afghanistan

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dc.authoridhttp://orcid.org/0000-0002-8861-7106en_US
dc.authoridhttp://orcid.org/0000-0002-8799-4604en_US
dc.authoridhttp://orcid.org/0000-0002-1441-6408en_US
dc.contributor.authorHusseini, Abbas Ali
dc.contributor.authorSaeed, Khwaja Mir Islam
dc.contributor.authorYurdcu, Esra
dc.contributor.authorBozdayı, A. Mithat
dc.date.accessioned2023-09-20T20:43:40Z
dc.date.available2023-09-20T20:43:40Z
dc.date.issued2020en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractBackground/Aims: This study gives a clue about genotypes, subgenotypes, and subtypes of hepatitis B (HBV), Hepatitis C (HCV), and Hepatitis D (HDV) viruses in general population of Afghanistan. Materials and Methods: A total of 234 Hepatitis B surface antigen (HBsAg), 44 anti-HCV, and 5 antidelta positive patients from 25–70- age group were studied through a rapid screening test among 5898 residents of Afghanistan. After quantifying viral load, genotyping of 61 HBV, 29 HCV, and 1 HDV samples were accomplished by sequencing of a segment of the HBV Pre S, HCV NS5B, and HDV Delta antigen regions, respectively. Clinically important variants of the HBV polymerase gene, the “a” determinant of HBsAg, HCV NS5B, and NS3 regions were assessed. Results: All HBV isolates were dispersed throughout the genotype D branch and ayw2 was the only subtypes found. The anti-HDV prevalence among HBsAg-positive individuals was 2.2% and the single HDV sample, from HDV genotype I. Analysis of HCV isolates revealed subtype HCV genotype 1b (HCV-1b) in 75.86%, HCV-3a in 20.69%, and HCV-3b in 3.44% patients. The observed mutant variants in the major hydrophilic region (MHR) of HBsAg were Y100 15%, Q101 5%, G102 15%, T115 45%, P120 5%, and T131 5%. Likewise, S213T 10%, Q215P 5%, and N248H 100% mutations were detected in the HBV polymerase region. C316N mutation was prevalent in 72.7% of HCV-1b participants. Conclusion: Genotypic variation in Afghan patients is in line with the ones existing in neighboring countries and regions. HBV genotypes D1, subtype ayw2, HDV RNA type I, and HCV RNA genotype 1b are likely to be dominant in Afghan patients.en_US
dc.identifier.doi10.5152/tjg.2020.19169en_US
dc.identifier.endpage666en_US
dc.identifier.issn2148-5607
dc.identifier.issue9en_US
dc.identifier.pmid33090103en_US
dc.identifier.scopus2-s2.0-85094118685en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage658en_US
dc.identifier.trdizinid408598en_US
dc.identifier.urihttps://hdl.handle.net/11363/5593
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/408598
dc.identifier.urihttps://doi.org/
dc.identifier.volume31en_US
dc.identifier.wosWOS:000583804200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHusseini, Abbas Ali
dc.language.isoenen_US
dc.publisherAVES, BÜYÜKDERE CAD 105-9, MECİDİYEKÖY, ŞİŞLİ, ISTANBUL 34394, TURKEYen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectHepatitis B virusen_US
dc.subjectHepatitis C virusen_US
dc.subjectHepatitis D virusen_US
dc.subjectgenotypeen_US
dc.subjectepidemiologyen_US
dc.subjectAfghanistanen_US
dc.titleMolecular epidemiology of Hepatitis B virus, Hepatitis C virus, and Hepatitis D virus in general population of Afghanistanen_US
dc.typeArticleen_US

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