Exploring neuronal mechanisms of osteosarcopenia in older adults

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dc.authoridTURKER, KEMAL SITKI/0000-0001-9962-075X
dc.authoridKaracan, Ilhan/0000-0002-7462-1358
dc.contributor.authorKaracan, Ilhan
dc.contributor.authorTurker, Kemal Sitki
dc.date.accessioned2024-09-11T19:52:01Z
dc.date.available2024-09-11T19:52:01Z
dc.date.issued2024
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractUntil recently, research on the pathogenesis and treatment of osteoporosis and sarcopenia has primarily focused on local and systemic humoral mechanisms, often overlooking neuronal mechanisms. However, there is a growing body of literature on the neuronal regulation of bone and skeletal muscle structure and function, which may provide insights into the pathogenesis of osteosarcopenia. This review aims to integrate these neuronal regulatory mechanisms to form a comprehensive understanding and inspire future research that could uncover novel strategies for preventing and treating osteosarcopenia. Specifically, the review explores the functional adaptation of weight-bearing bone to mechanical loading throughout evolutionary development, from Wolff's law and Frost's mechanostat theory to the mosaic hypothesis, which emphasizes neuronal regulation. The recently introduced bone osteoregulation reflex points to the importance of the osteocytic mechanoreceptive network as a receptor in this neuronal regulation mechanism. Finally, the review focuses on the bone myoregulation reflex, which is known as a mechanism by which bone loading regulates muscle functions neuronally. Considering the ageing-related regressive changes in the nerve fibres that provide both structural and functional regulation in bone and skeletal muscle tissue and the bone and muscle tissues they innervate, it is suggested that neuronal mechanisms might play a central role in explaining osteosarcopenia in older adults. image Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic neurons in the spinal cord and then to ganglionic neurons. Neuropeptides released from postganglionic sympathetic efferent nerves regulate bone formation and resorption processes. Additionally, osteocytes regulate skeletal muscle function by activating motor neurons in the spinal cord via afferent nerves. Disruption of this neuronal regulation mechanism can lead to bone loss and sarcopenia. imageen_US
dc.description.sponsorshipThe authors sincerely thank all the healthy volunteers, patients and fellow researchers who contributed to our previous experimental and clinical studies conducted over the past 15 years. These studies, focusing on the neurophysiology of bone and the reflex response induced by whole-body vibration, have greatly contributed to the foundation of this review.en_US
dc.identifier.doi10.1113/JP285666
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.pmid39119811en_US
dc.identifier.scopus2-s2.0-85200988549en_US
dc.identifier.urihttps://doi.org/10.1113/JP285666
dc.identifier.urihttps://hdl.handle.net/11363/7892
dc.identifier.wosWOS:001286550000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Physiology-Londonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240903_Gen_US
dc.subjectageingen_US
dc.subjectbone lossen_US
dc.subjectdysmobility syndromeen_US
dc.subjectmuscle weaknessen_US
dc.subjectosteocyteen_US
dc.subjectosteoporosisen_US
dc.subjectosteosarcopeniaen_US
dc.titleExploring neuronal mechanisms of osteosarcopenia in older adultsen_US
dc.typeArticleen_US

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