The number of prior pregnancy losses does not impact euploidy rates in young patients with idiopathic recurrent pregnancy loss

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dc.authoridYARKINER, ZALIHE/0000-0002-4766-6454
dc.authoridTurgut, Niyazi Emre/0000-0002-5986-3121
dc.contributor.authorTurgut, Niyazi Emre
dc.contributor.authorBoynukalin, Fazilet Kubra
dc.contributor.authorGultomruk, Meral
dc.contributor.authorYarkiner, Zalihe
dc.contributor.authorAbali, Remzi
dc.contributor.authorBahceci, Mustafa
dc.date.accessioned2024-09-11T19:50:11Z
dc.date.available2024-09-11T19:50:11Z
dc.date.issued2023
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractPurposeOur study aimed to determine the possible factors that might impact the probability of obtaining a euploid blastocyst following intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A) procedures in idiopathic recurrent pregnancy loss (RPL) patients.MethodsThis single-center retrospective cohort analysis included 180 oocyte retrieval cycles of 166 women under 35 years old and those diagnosed with idiopathic RPL according to American Society of Reproductive Medicine (ASRM) guidelines. Trophectoderm biopsy and next-generation sequencing (NGS) were the techniques used. Patients were stratified by the number of previous losses (Group A: 2, Group B: 3, and Group C: > 3).ResultsBaseline and embryological characteristics showed no statistically significant differences. The euploidy rate per analyzed blastocyst was comparable within the groups (63.3%, 58.2%, and 58.5%; p = 0.477). Logistic regression analyses confirmed that only the trophectoderm scores of A and B increased the probability of obtaining a euploid embryo [OR: 1.82, 95% CI (1.120-2.956), p: 0.016].ConclusionIt is concluded that there was no correlation between the number of previous losses and the chance of finding at least one euploid embryo in ICSI cycles of women younger than 35 years.en_US
dc.identifier.doi10.1007/s00404-023-07155-w
dc.identifier.endpage1575en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue5en_US
dc.identifier.pmid37466688en_US
dc.identifier.scopus2-s2.0-85165148750en_US
dc.identifier.startpage1567en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-023-07155-w
dc.identifier.urihttps://hdl.handle.net/11363/7580
dc.identifier.volume308en_US
dc.identifier.wosWOS:001033463100002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectComprehensive chromosomal screeningen_US
dc.subjectPrognostic factoren_US
dc.subjectIVFen_US
dc.subjectICSIen_US
dc.subjectBlastocysten_US
dc.titleThe number of prior pregnancy losses does not impact euploidy rates in young patients with idiopathic recurrent pregnancy lossen_US
dc.typeArticleen_US

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