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    Öğe
    ROLE OF INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3) IN THE DIAGNOSIS OF PANCREATIC ADENOCARCINOMA AND MONITORING TREATMENT RESPONSE
    (Carbone Editore, 2019) Bademler, Suleyman; Ucuncu, Whammed Zubeyr; Sari, Murat; Yasasever, Ceren Tilgen; Afsar, Cigdem Usul; Tastekin, Didem
    Purpose: Pancreatic cancer occurs rarely in humans, and it is one of the most fatal five cancer types with very poor prognosis. Early diagnosis of pancreatic cancer is difficult due to late presentation of symptoms. The purpose of our study was to evaluate the utility of IGFBP-3 and IGF-1 in early diagnosis of pancreatic cancer and in monitoring treatment response and contribute to the studies conducted in this regard. Methods: The study included 108 subjects, 54 of who were diagnosed with and followed-up for pancreatic cancer and 54 were healthy subjects. The results were compared between the two groups. The study was approved by the Istanbul Faculty of Medicine Ethics Committee. Results: The mean age of the patients included in the study was 54.42 years. IGF-1 levels and IGFBP-3 levels were significantly lower in pancreatic cancer patients than in the control group (respectively p = 0.002, 0.004). There was no difference between IGF-1 and IGFBP-3 levels in patients with distant metastasis (p > 0.05). IGF- 1 levels were significantly higher in patients who responded to chemotherapy than in those who did not respond to chemotherapy (p = 0.03). Conclusions: In our study, we observed that IGF-1 and IGHIP-3 levels can be used for the diagnosis of patients with pancreatic cancer and evaluation of treatment response and prognosis, and there is no significant difference in serum levels according to age, presence of distant metastasis, and gender.
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    Öğe
    The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer
    (MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2024) İlhan, Burak; Ender, Şenol; Kılıç, Berkay; Üçüncü, Muhammed; Serilmez, Murat; Yasasever, Ceren Tilgen; Soydinç, Hilal Oğuz; Kuras, Sibel; Erdoğan, Bekir; Alsaadoni, Hani; Karanlık, Hasan; Bademler, Süleyman
    Despite advances in cancer treatment, breast cancer (BC) remains one of the most common cancers affecting women worldwide. This study aimed to determine serum circFBXW7, circABCB10, and circ0103552 levels and compare BC patients and healthy controls to investigate their roles in the molecular mechanism of BC and the significance of these circRNAs in BC diagnosis. The study group consisted of 92 patients with BC and 31 healthy controls. Total RNA was isolated from serum samples. Following total RNA, complementary DNA was synthesized from this material. Following complementary DNA analysis, the circRNA levels were analyzed by the qRT-PCR method. Expression levels were evaluated in ∆Ct values. High ∆Ct values of circFBXW7 and circ0103552 and low ∆Ct values of circABCB10 were correlated with BC diagnosis (circFBXW7, p = 0.043, r = 0.183, circ0103552, p < 0.001, r = 0.321, circABCB10, p = 0.001, r = −0.291). According to Fold Change (FC) values, circFBXW7 (FC = 0.30) and circ0103552 (FC = 0.26) showed low expression in the patient group compared to the control group, while circABCB10 (FC = 11.09) showed high expression (p < 0.05, for all comparisons). We think that our study is one of the rare studies investigating the relationship between BC and serum circRNA levels. This study concludes that the significant downregulation of circFBXW7 and circ0103552 and the upregulation of circABCB10 are directly related to the diagnosis of BC and can be used for diagnosis, but further studies are needed to elucidate the molecular mechanism of the relationship between circRNAs and BC.