Immunohistochemical approach to obesity disease in terms of expression levels of glutathione s-transferase (sigma, zeta, theta) isozymes

Basit Öğe Kaydı
dc.authoridhttps://orcid.org/0000-0001-7194-7814en_US
dc.authoridhttps://orcid.org/0000-0001-7439-8099en_US
dc.authoridhttps://orcid.org/0000-0003-0511-6611en_US
dc.authoridhttps://orcid.org/0000-0003-0127-1753en_US
dc.authoridhttps://orcid.org/0000-0001-7710-4631en_US
dc.authoridhttps://orcid.org/0000-0002-8387-4146en_US
dc.authoridhttps://orcid.org/0000-0001-5649-954Xen_US
dc.authoridhttps://orcid.org/0000-0002-5892-3735en_US
dc.contributor.authorDavudov, Mahammad
dc.contributor.authorBuluş, Hakan
dc.contributor.authorDirican, Onur
dc.contributor.authorKaygın, Pınar
dc.contributor.authorŞimşek, Gülçin Güler
dc.contributor.authorYılmaz Sarıaltın, Sezen
dc.contributor.authorGürbüz, Fatıma Nurdan
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned2023-10-09T18:15:35Z
dc.date.available2023-10-09T18:15:35Z
dc.date.issued2023en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractObjectives: Obesity is a complex multifactorial disease with recently increasing prevalence and incidence. Several studies have been conducted to explain the ethiology, pathophysiology, epidemiology, molecular and genetic mechanisms, and effective treatments of obesity. Glutathione S-transferase (GST) S1, GSTZ1, and GSTT1 are essential enzymes for oxidative stress and metabolism-related disorders. For this purpose, we aimed to reveal the role of GSTS1, GSTZ1, and GSTT1 in obesity. Methods: The gastric tissue samples were taken from the patients diagnosed with obesity who underwent bariatric surgery in Ankara Keçiören Training and Research Hospital General Surgery Clinic between 2017 and 2019. Immunostaining was performed on paraffin-embedded tissues to evaluate GSTS1, GSTZ1, and GSTT1 expressions. Laboratory data of the patients were recorded. All the results were analyzed statistically. Results: Weak GSTS1 expression was observed in 38.1% of tissues and moderate in 6.3%. 37.3% of the tissues presented weak GSTZ1 expression, and 11 (8.7%) displayed moderate. There were weak GSTT1 expressions in 7.1% of the tissues and moderate 0.8% of them. A positive and statistically significant correlation was observed between GSTS1 and GSTT1 expression levels ((r) = 0.028, p = 0.010; p < 0.05). There were no significant differences between expression levels and gender, age, comorbidities, and medication usage (p > 0.05). Conclusions: GSTs, in particular GSTS1, GSTT1, and GSTZ1, might contribute to molecular mechanisms and the progression of obesity. In our study, GSTS1, GSTT1, and GSTZ1 were found to be moderately expressed in gastric tissues taken from obese patients. However, new studies using more samples and advanced techniques are needed to elucidate the relationship.en_US
dc.identifier.doi10.18621/eurj.1121110en_US
dc.identifier.endpage554en_US
dc.identifier.issn2149-3189
dc.identifier.issue3en_US
dc.identifier.startpage543en_US
dc.identifier.trdizinid1165321en_US
dc.identifier.urihttps://hdl.handle.net/11363/5825
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1165321
dc.identifier.urihttps://doi.org/
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDirican, Onur
dc.language.isoenen_US
dc.publisherPrusa Medikal Yayıncılık Limited Şirketien_US
dc.relation.ispartofThe European Research Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectObesityen_US
dc.subjectXenobioticsen_US
dc.subjectPhase II enzymesen_US
dc.subjectGSTS1en_US
dc.subjectGSTZ1en_US
dc.subjectGSTT1en_US
dc.subjectImmunohistochemistryen_US
dc.titleImmunohistochemical approach to obesity disease in terms of expression levels of glutathione s-transferase (sigma, zeta, theta) isozymesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
document (21).pdf
Boyut:
687.5 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale / Article
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.56 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Diğer Atıf Dizinlerdeki Yayınlar
TR-Dizin İndeksli Yayınlar Koleksiyonu