GSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian cancer

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dc.authoridhttps://orcid.org/0000-0003-3288-0965en_US
dc.authoridhttps://orcid.org/0000-0003-0127-1753en_US
dc.authoridhttps://orcid.org/0000-0003-0511-6611en_US
dc.authoridhttps://orcid.org/0000-0002-5892-3735en_US
dc.authoridhttps://orcid.org/0000-0002-8387-4146en_US
dc.authoridhttps://orcid.org/0000-0001-7710-4631en_US
dc.authoridhttps://orcid.org/0000-0002-5222-5928en_US
dc.authoridhttps://orcid.org/0000-0002-1377-2021en_US
dc.authoridhttps://orcid.org/0000-0002-9696-6613en_US
dc.contributor.authorÖzer, Gizem
dc.contributor.authorKaygın, Pınar
dc.contributor.authorDirican, Onur
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorYılmaz Sarıaltın, Sezen
dc.contributor.authorŞimşek, Gülçin Güler
dc.contributor.authorErdem, Ayşegül
dc.contributor.authorKılıç, Murat
dc.contributor.authorÇoban, Tülay
dc.date.accessioned2023-10-08T13:50:39Z
dc.date.available2023-10-08T13:50:39Z
dc.date.issued2023en_US
dc.departmentSağlık Hizmetleri Meslek Yüksekokuluen_US
dc.description.abstractObjectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in the Western world. Ovarian carcinomas are detected in an advanced stage of the disease in approximately 80% of the patients. Glutathione S-transferases (GSTs) are an important family involved in the detoxification of several xenobiotics. Thus, this mechanism protects tissues from the harmful effects of oxidative stress and chemical-induced damages. The expression of them may contribute to the characteristics of ovarian carcinoma as they can metabolise both exogenous and endogenous compounds, which are implicated in the development of ovarian cancer. Therefore, our aim was to determine the expressions of GST Mu 1 (GSTM1), GST Pi 1 (GSTP1), and also p53, which is a tumor suppressor gene, in benign and malign ovarian tumors and metastasis tissues. Methods: A total of the 99 patients with ovarian tumor enrolled in the study. Thirty-one of the tissues was benign tumor, 17 was malign tumor and 51 was metastasis. The immunohistochemical GSTM1, GSTP1, and p53 staining characteristics of these tissues were investigated. Results: The highest GSTM1, GSTP1, and p53 expression was noted in the malignant group followed by the metastasis group. GSTP1 expression was significantly higher in malignant tissues than benign ones (p = 0.015). No statistically significant difference was observed in the level of GSTM1 expression between groups (p = 0.524). p53 expression was significantly higher in the metastasis and malignant tissues than the benign ones (p < 0.001). Conclusions: The higher expressions of GSTP1 and p53 in malignant and metastasis tissues than benign ones indicate that these expressions could be important biomarkers in ovarian cancer development and progression. Further studies with more cases are required to confirm the results of our present study.en_US
dc.identifier.doi10.18621/eurj.1112116en_US
dc.identifier.endpage483en_US
dc.identifier.issn2149-3189
dc.identifier.issue3en_US
dc.identifier.startpage477en_US
dc.identifier.trdizinid1165310en_US
dc.identifier.urihttps://hdl.handle.net/11363/5824
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1165310
dc.identifier.urihttps://doi.org/
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorDirican, Onur
dc.language.isoenen_US
dc.publisherPrusa Medikal Yayıncılık Limited Şirketien_US
dc.relation.ispartofThe European Research Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectOvary carcinomaen_US
dc.subjectGlutathione-S-transferaseen_US
dc.subjectP53en_US
dc.subjectImmunohistochemistryen_US
dc.titleGSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian canceren_US
dc.typeArticleen_US

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