A preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disorders

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dc.authorscopusid56152961400
dc.authorscopusid57203920647
dc.authorscopusid24725733300
dc.authorscopusid8076988000
dc.authorscopusid57203916626
dc.authorscopusid55257618200
dc.authorscopusid16548727600
dc.contributor.authorSener, Elif Funda
dc.contributor.authorŞahin, Mustafa Çağlar
dc.contributor.authorTaheri, Serpil
dc.contributor.authorBayramov, Keziban Korkmaz
dc.contributor.authorMarasli, Mert Kahraman
dc.contributor.authorZararsız, Gökmen
dc.contributor.authorCanpolat, Mehmet
dc.date.accessioned2024-09-11T19:58:35Z
dc.date.available2024-09-11T19:58:35Z
dc.date.issued2017
dc.departmentİstanbul Gelişim Üniversitesien_US
dc.description.abstractObjective: Autism spectrum disorders (ASDs) is a heterogeneous neuropsychiatric disorder with widespread abnormalities of social interaction and communication, showing severely restricted interests and extreme repetitive behavior. The relationship between aggressive behavior, insensitivity to pain, and ASDs could not be explained completely. Therfore, we aimed to contribute to the etiology by examining the gene expressions of OPRL1, TACR1, and HTR1E in patients with ASDs. Methods: This study was held in the Genome and Stem Cell Research Center of Erciyes University. In this present study, the expressions of OPRL1, TACR1, and HTR1E genes were studied in 22 ASD patients and 14 healthy controls. Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) was used for gene expression studies. Results: There was a statistically significant difference in terms of the expression of the three genes, which we examined between the ASD patient and control groups. Positive and strong correlations were obtained between the three gene expressions in the ASD group and this finding was found to be statistically significant. Conclusions: Considering all these findings, large-scale and new researches are needed for revealing the roles of genes and their pathways which are related to aggression and insensitivity to pain in ASDs. Our results will lead to new research studies in this field. © 2017 The Author(s).en_US
dc.description.sponsorshipErciyes Üniversitesien_US
dc.description.sponsorshipWe would like to thank Erciyes University Genome and Stem Cell Center.en_US
dc.identifier.doi10.1080/24750573.2017.1293248
dc.identifier.endpage29en_US
dc.identifier.issn2475-0573en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85053532902en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1080/24750573.2017.1293248
dc.identifier.urihttps://hdl.handle.net/11363/8525
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240903_Gen_US
dc.subjectAggression; Autism spectrum disorders; Expression; Insensitivity to painen_US
dc.titleA preliminary study of the genes related to aggression and insensitivity to pain in autism spectrum disordersen_US
dc.typeArticleen_US

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