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  • Küçük Resim
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    Beslenme Durumunun ve Beslenme ile İlişkili Bazı Hastalıkların Saptanmasında Boyun Çevresi Ölçümü
    (Kafkas Üniversitesi Tıp Fakültesi, 2021) Bayram, Hatice Merve; Margot Çelik, Zehra; Güneş, Fatma Esra
    Besin ögeleri alımı ile besin ögeleri gereksinmesi arasındaki dengenin sağlanması optimal sağlık için önem taşımaktadır. Beslenme durumunun saptanması bu açıdan önemlidir. Boyun çevresi ölçümü (Neck circumference-NC) beslenme durumunun saptanmasında kullanılan antropometrik ölçümlerden biri olup, karmaşık yöntemlere gerek kalmadan sonuca ulaşmaya yardımcı olan basit bir tekniktir. Ayrıca NC erişilebilir ve ölçümü kolaydır, bunun yanı sıra gün içerisinde değişiklik göstermediği için kullanılabilirliği araştırılmaktadır. Bu derlemenin amacı, NC ölçümü ile diğer antropometrik ölçümlerin, beslenme ile ilintili bazı hastalıkların, ilgili biyokimyasal bulguların ve metabolitlerin arasındaki ortaya konulmuş ilişkilerin incelenmesidir. Bu amaçla yapılan literatür taraması sonucunda, NC obezite ve metabolik sendrom riski ile yüksek korelasyon göstermesinin yanı sıra diğer antropometrik ölçümlerle de (vücut ağırlığı, beden kütle indeksi, bel çevresi, kalça çevresi ve bel/kalça oranı) ilişkili olabileceği görülmüştür. Ayrıca NC, insülin direnci, tip 2 diyabet, hipertansiyon, hiperlipidemi, kardiyovasküler hastalıklar ve obstrüktif uyku apnesi sendromunun tanımlanmasında kullanılabilecek bir ölçüm aracı olarak görülmektedir.
  • Küçük Resim
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    Comparison of several anthropometric measurements and blood lipid‑related indexes in metabolic-dysfunction associated fatty liver disease in adults: A cross-sectional study
    (YILDIZ TECHNICAL UNIV, YILDIZ CAMPUS, BESIKTAS, ISTANBUL 34349, TURKEY, 2024) Bayram, Hatice Merve; İliaz, Raim; Öztürkcan, S. Arda; Dündar, Bagnu; Güneş, Fatma Esra
    Dyslipidemia is strongly related to metabolic-dysfunction associated fatty liver disease (MAFLD). Therefore, the lipid profile may be a potential indicator of defining MAFLD. Anthropometric measurements are widely used as simple and practicable tools to screen metabolic dysfunction, and no study determined the relationship between anthropometric measurements and blood lipid-related indexes. The aim of this study was to examine the relationship between several anthropometric measurements and blood lipid-related indexes in MAFLD patients. This study was conducted among 123 MAFLD patients in a private University Hospital in Istanbul, Turkey, between 01.06.2021 – 30.12.2021. Anthropometric and biochemical measurements were taken from all patients. Hepatic steatosis was determined using ultrasonography. SPSS was used to analyze the data. Neck circumference (NC) was moderately associated with triglyceride glucose index (TyG) in both genders. It was found that there was a moderate correlation between NC and cardiometabolic index (CMI), triglyceride (TG), and triglyceride to high-density lipoprotein ratio (TG/HDL-C) in women, whereas it was weakly correlated with CMI index in men. Neck-to-height ratio (NHtR) was moderately associated with CMI, and TyG indexes in women, while it was weakly correlated with TyG index in men. There was a moderate association between waist-to-hip ratio (WHR) and low-density lipoprotein (LDL-C) in women. However, it was only weakly correlated with CMI index in men. It was observed that the waist-to-height ratio (WHtR) was only linked with TyG index in men. Additionally, the body mass index (BMI) and blood lipid-related indicators had no association. Our finding suggests that both NC and NHtR could be used to predict the risk of dyslipidemia in MAFLD, especially among women.
  • Küçük Resim
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    The relationship between polyphenols and miRNAs: A novel therapeutic strategy for metabolic associated fatty liver disease
    (KARE PUBL, Göztepe Mah. Fahrettin Kerim Gökay Caddesi. No: 200/A D:2 Çemenzar - Kadıköy, İSTANBUL 34720, TURKEY, 2021) Bayram, Hatice Merve; Eren, Fatih; Güneş, Fatma Esra
    Metabolic-associated fatty liver disease (MAFLD) is a public health problem that is increasingly recognized, currently affecting up to a quarter of the world’s adult population. Although a biopsy is the current gold standard to diagnose MAFLD, there are potentially serious complications, making it inadequate. Thus far, noninvasive methods have not been able to determine the stage and the subtype of MAFLD. The development and prognosis of MAFLD are modulated by epigenetic factors, including microRNAs (miRNAs), which may be potential biomarkers for MAFLD. Polyphenols, found in many fruits and vegetables, may be useful, as they alter gene expression with epigenetic factors, such as miRNAs. This review presents an overview of the relationship between polyphenols and miRNAs in MAFLD. The literature suggests that miRNAs could be used as a diagnostic method for MAFLD, especially miRNA-122 and miRNA-34a. However, though it has been demonstrated that polyphenols may contribute to improving MAFLD, to our knowledge, no study to date has shown the relationship between polyphenols and miRNAs in MAFLD. The exact mechanisms of polyphenols on miRNAs in MAFLD remain unclear. Future studies may provide hope for diet therapy for MAFLD patients as well as the development of polyphenol-related foods or drugs that target miRNAs to treat MAFLD.