Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats

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dc.authorid0000-0001-5122-4977en_US
dc.authorid0000-0003-3363-1290en_US
dc.authorid0000-0003-0804-1475en_US
dc.authorid0000-0003-1193-168Xen_US
dc.authorid0000-0003-2419-8587en_US
dc.authorid0000-0002-2091-9298en_US
dc.authorid0000-0003-4185-4363en_US
dc.authorid0000-0002-8258-6118en_US
dc.contributor.authorTüzüner Alev, Burçin
dc.contributor.authorTunalı, Sevim
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorTunalı Akbay, Tuğba
dc.contributor.authorYanardağ, Refiye
dc.contributor.authorYarat, Ayşen
dc.date.accessioned2023-10-10T09:57:34Z
dc.date.available2023-10-10T09:57:34Z
dc.date.issued2023en_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.description.abstractValproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative metabolism in gastric tissue and whether chard ameliorates these effects. The Sprague Dawley rats were divided into four groups (n=8); control, chard-given control, valproic acid, and chard-given valproic acid. The aqueous extracts of chard leaves were given 1 h before the administration of valproic acid for 7 days. On the 8th day, the animals were sacrificed under anesthesia and gastric tissues were homogenized. When compared to the control group, valproic acid significantly increased malondialdehyde and catalase activity, while superoxide dismutase activity decreased. Chard administration increased glutathione and, sialic acid levels and decreased malondialdehyde levels and superoxide dismutase activity in the valproic acid group. Based on these findings, since chard increased gastric sialic acid levels, we may suggest that chard may protect gastric mucosa may be through its antioxidant effects.en_US
dc.identifier.doi10.3153/FH23013en_US
dc.identifier.endpage147en_US
dc.identifier.issn2602-2834
dc.identifier.issue2en_US
dc.identifier.startpage139en_US
dc.identifier.trdizinid1165593en_US
dc.identifier.urihttps://hdl.handle.net/11363/5827
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1165593
dc.identifier.urihttps://doi.org/
dc.identifier.volume9en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorTüzüner Alev, Burçin
dc.language.isoenen_US
dc.publisherScientificWebJournals (SWJ) Özkan Özdenen_US
dc.relation.ispartofFood and Healthen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectGastric tissueen_US
dc.subjectValproic aciden_US
dc.subjectCharden_US
dc.subjectSialic aciden_US
dc.subjectOxidative stressen_US
dc.titleChard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered ratsen_US
dc.typeArticleen_US

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