Exercise and Caloric Restriction Improves Liver Damage in Metabolic Syndrome Model

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dc.authoridhttps://orcid.org/0000-0003-2143-0088en_US
dc.authoridhttps://orcid.org/0000-0001-5122-4977en_US
dc.authoridhttps://orcid.org/0000-0003-1193-168Xen_US
dc.authoridhttps://orcid.org/0000-0003-0804-1475en_US
dc.authoridhttps://orcid.org/0000-0002-2091-9298en_US
dc.authoridhttps://orcid.org/0000-0003-2419-8587en_US
dc.authoridhttps://orcid.org/0000-0001-7444-6193en_US
dc.authoridhttps://orcid.org/0000-0002-8258-6118en_US
dc.contributor.authorGenç Kahraman, Nevin
dc.contributor.authorAlev Tüzüner, Burçin
dc.contributor.authorİpekçi, Hazal
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorTunali Akbay, Tuğba
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorŞener, Göksel
dc.contributor.authorYarat, Ayşen
dc.date.accessioned2023-10-27T15:58:26Z
dc.date.available2023-10-27T15:58:26Z
dc.date.issued2021en_US
dc.departmentDiş Hekimliği Fakültesien_US
dc.description.abstractObjective: Detecting the level of antioxidant and tissue damage that can occur in liver tissue induced metabolic syndrome by a high fructose diet in rats and the changes after exercise and/or caloric restriction. Materials and Methods: Sprague-Dawley male rats were divided into five groups: control (C), metabolic syndrome (M), metabolic syndrome with exercise (ME), metabolic syndrome with caloric restriction (MCR), and metabolic syndrome with exercise and caloric restriction (MECR). To induce metabolic syndrome, a 10% fructose solution was given to rats in drinking water for 3 months. Exercise and caloric restriction were applied to the related groups for 6 weeks after the induction of metabolic syndrome. Glucose in the blood, lipid peroxidation (LPO), sialic acid (SA), hexosamine, mucin, fucose, glutathione (GSH) levels, alkaline phosphatase (ALP), tissue factor (TF), superoxide dismutase (SOD), catalase (CAT), and glutathione-Stransferase (GST) activities were measured in rat liver homogenates. Results: In the liver, LPO levels increased and TF activities decreased in the M group compared to the C group and increased in the MCR and MECR groups compared to M group. GSH levels, SOD, and CAT activities decreased in M compared to C group and increased more significantly in MECR group compared to M group. SA levels increased in MCR and MECR groups compared with M group. Fucose levels also increased in MECR compared with the all others. Conclusion: Liver tissue damage that occurs after a fructose diet and decreased antioxidant levels was shown to improve best in combined exercise and caloric restriction treatment (MECR group).en_US
dc.identifier.doi10.26650/EurJBiol.2021.912661en_US
dc.identifier.endpage21en_US
dc.identifier.issn2602-2575
dc.identifier.issn2618-6144
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85120749365en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage15en_US
dc.identifier.trdizinid460847en_US
dc.identifier.urihttps://hdl.handle.net/11363/6096
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/460847
dc.identifier.urihttps://doi.org/
dc.identifier.volume80en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorAlev Tüzüner, Burçin
dc.language.isoenen_US
dc.publisherİstanbul Üniversitesi Yayınevien_US
dc.relation.ispartofEuropean Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectMetabolic syndromeen_US
dc.subjectExerciseen_US
dc.subjectCaloric restrictionen_US
dc.subjectAntioxidant-oxidant parametersen_US
dc.titleExercise and Caloric Restriction Improves Liver Damage in Metabolic Syndrome Modelen_US
dc.typeArticleen_US

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