Exercise and Caloric Restriction Improves Liver Damage in Metabolic Syndrome Model
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İstanbul Üniversitesi Yayınevi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
Objective: Detecting the level of antioxidant and tissue damage that can occur in liver tissue induced metabolic syndrome by a high fructose diet in rats and the changes after exercise and/or caloric restriction. Materials and Methods: Sprague-Dawley male rats were divided into five groups: control (C), metabolic syndrome (M), metabolic syndrome with exercise (ME), metabolic syndrome with caloric restriction (MCR), and metabolic syndrome with exercise and caloric restriction (MECR). To induce metabolic syndrome, a 10% fructose solution was given to rats in drinking water for 3 months. Exercise and caloric restriction were applied to the related groups for 6 weeks after the induction of metabolic syndrome. Glucose in the blood, lipid peroxidation (LPO), sialic acid (SA), hexosamine, mucin, fucose, glutathione (GSH) levels, alkaline phosphatase (ALP), tissue factor (TF), superoxide dismutase (SOD), catalase (CAT), and glutathione-Stransferase (GST) activities were measured in rat liver homogenates. Results: In the liver, LPO levels increased and TF activities decreased in the M group compared to the C group and increased in the MCR and MECR groups compared to M group. GSH levels, SOD, and CAT activities decreased in M compared to C group and increased more significantly in MECR group compared to M group. SA levels increased in MCR and MECR groups compared with M group. Fucose levels also increased in MECR compared with the all others. Conclusion: Liver tissue damage that occurs after a fructose diet and decreased antioxidant levels was shown to improve best in combined exercise and caloric restriction treatment (MECR group).
Açıklama
Anahtar Kelimeler
Metabolic syndrome, Exercise, Caloric restriction, Antioxidant-oxidant parameters
Kaynak
European Journal of Biology
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
80
Sayı
1
