Yazar "Deveci, Burak" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • Küçük Resim
    Öğe
    Akut Lenfoblastik Lösemili Hastalarda Mikafungin Profilaksisi
    (İstanbul Gelişim Üniversitesi Yayınları / Istanbul Gelisim University Press, 2022) Deveci, Burak; Yücel, Orhan Kemal; Kublashvili, George; İltar, Utku; Ataş, Ünal; Turhan, Özge; Saba, Rabin
    Amaç: Hematolojik maligniteli hastaların tedavisindeki gelişmelere rağmen invaziv fungal infeksiyon (İFİ), bu hastalıkların seyri sırasında önemli bir morbidite ve mortalite nedeni olmaya devam etmektedir. Antilösemik tedavinin başarısı ve komplikasyon gelişme riskini azaltabilmesi nedeniyle antifungal profilaksi önem arz etmektedir. Yöntem: Bu retrospektif çalışmada profilaktik bir antifungal olarak mikafunginin akut lenfoblastik lösemi (ALL) hastalarındaki etkinliği ve güvenilirliliği değerlendirilmiştir. Çalışmaya erişkin yaş grubundaki ALL tanısı ile indüksiyon, reindüksiyon veya kurtarma tedavisi alan ve tedavi sırasında mikafungin ile antifungal profilaksi uygulanan 36 hasta ve bu hastaların almış oldukları toplam 113 kemoterapi kürü dahil edilmiştir. Hastaların tamamına indüksiyon, reindüksiyon ve konsolidasyon tedavileri sırasında mikafungin 50 mg/gün intravenöz profilaksisi verilmiştir. Çalışmanın sonlanım noktası olarak ise; tedavinin tamamlanması, profilaksi altında ampirik, preemptif veya hedefe yönelik antifungal değişikliği ve herhangi bir nedenle ölüm kabul edilmiştir. Bulgular: Çalışmamızın sonuçları incelendiğinde ALL hastalarında İFİ varlığı ile sağ kalım arasındaki kuvvetli ilişki ilk başta dikkati çekmektedir. Bununla birlikte; yan etki veya ilaç etkileşimi nedeniyle tedaviyi kesme gerekliliğinin olmaması, düşük preemptif antifungal ihtiyacı, ALL hastalarında mikafungin profilaksisinin etkinliğini göstermiştir. Sonuç: Etkin ve güvenilir bir antifungal profilaksi stratejisi bu grup hastalar için hayati önem taşımaktadır, hayat kurtarıcı olabilmektedir.
  • Küçük Resim
    Öğe
    Determinants of clinical course and mortality in COVID19 patients with hematological disorders: real life data from a single center
    (Prusa Medical Publishing, 2022) Deveci, Burak; Döşemeci, Levent; Aslan, Ayşe; Asal, Gökhan; Üstün, Bilge; Yıldırımer Akar, Meltem; Toptaş, Tayfur; Yavuz Taşlıpınar, Mine; Saba, Rabin
    Objectives: Patients with hematological disorders are often immunosuppressive due to underlying diseases, immunosuppressive therapies or cytotoxic chemotherapeutics. In the case of coronavirus disease 2019 (COVID19), they are at high risk of poor prognosis. Therefore, the present study aimed to evaluate the determinants of clinical course and mortality in COVID-19 patients with hematological disorders. Methods: Sixty-two hospitalized patients older than 18 years with documented COVID-19 and hematological disorders were included in the study. The clinical and laboratory data of the patients were recorded. Age, gender, overall follow-up time, duration of hospitalization, neutropenia, D-dimer levels, disease status, presence of underlying diseases, prior autologous and allogeneic stem cell transplant, immunosuppressive drug use, chemotherapy within 28 days, pneumonia, secondary bacterial infection, intubation, survival and mortality of the patients were evaluated. Results: Twenty-eight (45.2%) of 62 patients died due to COVID-19 and its complications. It was observed that presence of pneumonia, secondary bacterial infection, intubation, neutropenia developed after the diagnosis of COVID-19, and elevated D-dimer levels were associated with significant mortality. A D-dimer level of > 1.2 µg/dL was found to be associated with 5.02 fold increase in the risk of death, with 60.7% sensitivity and 76.5% specificity. Presence of rheumatologic diseases also affected survival negatively. Conclusions: D-dimer levels have high predictive value for mortality. Considering the identified risk factors, it can be concluded that broad spectrum antibiotics can be administered earlier for prevention of high mortality rates in COVID-19 patients with underlying hematological disorders. These observations can give confidence to clinicians that delivery of effective anticancer regimens should continue during this difficult pandemic.
  • Küçük Resim
    Öğe
    Hematopoietic Stem Cell Transplantation for Patients with Paroxysmal Nocturnal Hemoglobinuria with or without Aplastic Anemia: A Multicenter Turkish Experience
    (Erkan Mor, 2021) Yılmaz, Fergün; Soyer, Nur; Cengiz Seval, Güldane; Civriz Bozdağ, Sinem; Topçuoğlu, Pervin; Ünal, Ali; Kaynar, Leylagül; Özgür, Gökhan; Sucak, Gülsan; Göker, Hakan; Velet, Mustafa; Özdoğu, Hakan; Yılmaz, Mehmet; Kaya, Emin; Salim, Ozan; Deveci, Burak; Karadoğan, İhsan; Saydam, Güray; Şahin, Fahri; Vural, Filiz
    Objective: Although inhibition of the complement system at different steps is a promising therapy modality in patients with paroxysmal nocturnal hemoglobinuria (PNH), allogeneic hematopoietic stem cell transplantation (HCT) is still the only curative therapy, especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with aplastic anemia (PNH-AA) or without. Materials and Methods: Thirty-five PNH/PNH-AA patients who were treated with allogeneic HCT in 10 transplantation centers in Turkey were retrospectively analyzed. Results: Sixteen (45.7%) and 19 (54.3%) patients were diagnosed with classical PNH and PNH-AA, respectively. The median age of the patients was 32 (18-51) years. The 2-year overall survival (OS) rate and rate of graft-versus-host disease-free, failure-free survival (GFFS) was 81.2% and 78.1%, respectively. The 2-year OS in cases of classical PNH and PNH-AA was 81.3% and 79.9%, respectively (p=0.87), and 2-year GFFS in cases of PNH and PNH-AA was 79% and 76% (p=0.977),without statistical significance. The OS and GFFS rates also did not differ between transplantations with matched sibling donors (MSDs) and matched unrelated donors (MUDs). Conclusion: Allogeneic HCT with MSDs or MUDs is a good option for selected patients with classical PNH and PNH-AA. In particular, patients with debilitating and refractory hemolysis and patients with bone marrow failure might form an excellent group of candidates for allogeneic HCT.
  • Küçük Resim Yok
    Öğe
    Long-Term Outcomes of Allogeneic Stem Cell Transplantation for Relapsed/Refractory Hodgkin and Non-Hodgkin Lymphoma: Multi-center Experience from Turkey
    (Springer India, 2024) Uysal, Ayse; Soyer, Nur Akad; Ozdogu, Hakan; Goker, Hakan; Cinar, Olgu Erkin; Deveci, Burak; Yilmaz, Asu Fergun
    This multicenter retrospective study evaluated the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on survival and safety in patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A total of 110 patients with R/R HL or NHL who underwent allo-HSCT between July 2007 and October 2022 at 7 adult stem cell transplant centers were evaluated. Progression-free survival (PFS), graft versus host disease-free survival (GRFS), and overall survival (OS) were the primary endpoints, and NRM was the secondary endpoint. Forty-one (37.3%) of the total patients were diagnosed with HL, 69 (62.7%) with NHL. The median age at the time of allo-HCT was 39.5 years (16-67), of which 66 (60%) were male. The median follow-up was 67.5 +/- 8.1 months, and the rates of 5-year OS, PFS, and GRFS were 38.4%, 37%, and 34.8%, respectively. On multivariate analysis, CR/PR disease status after allo-HCT was significantly associated with longer PFS (HR: 13.47, 95% CI: 5.80-31.26, p = 0.000) and OS (HR: 5.23, 95% CI: 2.93-9.34, p = 0.000). CR/PR disease status after allo-HCT (HR: 5.79, 95% CI: 3.22-10.40, p = 0.000) and grade 1-2 acute GvHD (HR: 2.33, 95% CI: 1.25-4.35, p = 0.008) were significantly associated with longer GRFS. The 5-year cumulative incidence of NRM was 24.8% (95% CI, 12.5-36.7). The most common conditioning regimen was reduced intensity. Transplant outcomes are not influenced by disease subtype. However, the achievement of a CR/PR response after allo-HCT significantly prolongs OS, PFS and GRFS. In addition, the presence of acute grade 1-2 GvHD was found to be another factor prolonging GRFS. These results support the feasibility of allo-HCT, especially in heavily treated patients.